Laboratory of Ari Helenius
The laboratory of Ari Helenius is localized in the Institute of Biochemistry (ibc) at ETH Zürich (ETHZ), Switzerland (see ‘Contact us‘).
Our group studies interactions that occur between incoming animal viruses and their host cells during the infectious cycle. Using cellular and molecular techniques in combination with video microsopy in live cells, we investigate how virus particles bind to cells, how they are internalized by endocytosis, and how they are transported to various organelles such as endosomes and the endoplasmic reticulum. We are also analysing how the viral genome and accessory proteins escape into the cytosol, and how they enter through the nuclear pore complexes into the nucleoplasm.
Go to the main page of the Ari Helenius’ laboratory website
This website is dedicated to the people in the Ari’s lab working on bunyavirus entry. See ‘Team members‘.
The bunyavirus team
Our main interest concerns all the aspects of the host-bunyavirus interactions, from the transmission to the viral genome release. As introduced, our approaches involve various cellular and molecular techniques in combination, essentially, with fluorescence microscopy and flow cytometry. You will find a short introduction about our current work in the following links.
1. Biological significance
2. Bunyaviridae
3. Bunyavirus transmission
4. Bunyavirus entry
